陈秋铭,江南大学食品科学与技术国家重点实验室、开云Kaiyun副研究员,硕士生导师,主要从事食品酶高效挖掘、定向分子改造与功能性蛋白质配料生物制备研究,借助以分子动力学模拟技术为主导的计算机技术,进行新型食品酶、功能性蛋白质的构效解析,为食品配料的高效生物制备提供理论依据和技术指导。主持国家自然科学基金青年基金、江苏省自然科学青年基金等科研项目;以第一/通讯作者在Trends Food Sci Tech、Crit Rev Food Sci Nutr、J Agric Food Chem、J Dairy sci等期刊发表SCI论文10余篇,编著英文著作1部(共同主编)。
教育背景:
2016.09-2019.12,江南大学,食品科学与工程,博士
2017.9-2019.9,哈佛大学,化学和化员工物学系,博士联合培养
2013.09-2016.06,江南大学,食品科学与工程,硕士
2009.09-2013.06,西北农林科技大学,食品科学与工程,学士
研究方向:
食品酶工程、食品功能配料生物制造
1.国家自然科学基金青年基金(32001636),2021.01-2023.12,主持。
2.江苏省自然科学基金青年基金(BK20200594),2020.07-2023.06,主持。
英文专著:
1. Mu W*, Zhang W,Chen Q.Novel enzymes for functional carbohydrates production: From scientific research to application in health food industry [M].Springer Nature, 2021. (ISBN 978-981-336-021-1)
代表性学术论文:
1.Chen, Q., Wu, Y., Huang, Z., Zhang, W., Chen, J., and Mu, W.*(2022) Cold-active enzymes in the dairy industry: Insight into cold adaption mechanisms and their applications.Trends in Food Science & Technology, -.
2.Chen, Q., Zhang, W., & Mu, W.*(2021). Molecular Dynamics Simulation for Food Enzyme Engineering: Why This Technique Should Be Encouraged To Learn.Journal of Agricultural and Food Chemistry, 69(1), 4-6.
3.Chen Q., Wu Y., Huang Z., & Zhang W.*(2021) Kinetic study and molecular dynamics simulation of two novel mannose isomerases.Catalysis Science & Technology11(17):5898-5907,
4.Chen Q, Wu Y., Huang Z., Zhang W., & Mu W.*(2021) Molecular Characterization of a Mesophilic Cellobiose 2-Epimerase That Maintains a High Catalytic Efficiency at Low Temperatures.Journal of Agricultural and Food Chemistry,69(29):8268-8275,
5.Chen, Q., Xu W., Wu H., Guang C.*, Zhang, W.*, & Mu, W. An overview of D-galactose utilization through microbial fermentation and enzyme-catalyzed conversion.Applied Microbiology and Biotechnology, 1-10,
6.Chen, Q., Xiao, Y., Zhang, W., Stressler, T., Fischer, L., Jiang, B., & Mu, W.*(2020). Computer-aided search for a cold-active cellobiose 2-epimerase.Journal of Dairy Science, 103(9), 7730-7741.
7.Chen, Q., Xiao, Y., Zhang, W., & Mu, W.*(2019). Current methods and applications in computational protein design for food industry. Critical Reviews in Food Science and Nutrition, (1), 1-12.
8.Chen, Q., Xiao, Y., Zhang, W., Zhang, T., Jiang, B., Stressler, T., Fischer, L., & Mu, W.*(2018). Current research on cellobiose 2-epimerase: Enzymatic properties, mechanistic insights, and potential applications in the dairy industry.Trends in Food Science & Technology, 82, 167-176.
9.Chen, Q., He, W., Yan, X., Zhang, T., Jiang, B., Stressler, T., Fischer, L., & Mu, W.*(2018). Construction of an enzymatic route using a food-grade recombinantBacillus subtilisfor the production and purification of epilactose from lactose.Journal of Dairy Science, 101(3), 1872-1882.
10.Chen, Q., Xiao, Y., Shakhnovich, E. I.*, Zhang, W.*, & Mu, W. (2019). Semi-rational design and molecular dynamics simulations study of the thermostability enhancement of cellobiose 2-epimerases.International Journal of Biological Macromolecules, 154, 1356-1365.
11.Chen, Q., Levin, R., Zhang, W., Zhang, T., Jiang, B., Stressler, T., Fischer, L., & Mu, W.*(2017). Characterisation of a novel cellobiose 2-epimerase from thermophilicCaldicellulosiruptor obsidiansisfor lactulose production.Journal of the Science of Food and Agriculture, 97(10), 3095-3105.
12.Chen, Q., Zhang, W., Zhang, T., Jiang, B., & Mu, W.*(2015). Characterization of an epilactose-producing cellobiose 2-epimerase fromThermoanaerobacterium saccharolyticum.Journal of Molecular Catalysis B: Enzymatic (Continued as Molecular Catalysis), 116, 39-44.
13.Wu, Y., Huang, Z., Zhang, W., Guang, C.,Chen, Q.*,& Mu, W. (2022). Characterization of a Novel Mannose Isomerase from Stenotrophomonas rhizophila and Identification of Its Possible Catalytic Residues.Molecular Biotechnology, 1-10.
14.Chen, Q., Zhang, W., Zhang, T., Jiang, B., & Mu, W.*(2015). Characterization of an epilactose-producing cellobiose 2-epimerase fromThermoanaerobacterium saccharolyticum.Journal of Molecular Catalysis B: Enzymatic, 116, 39-44.
15.Wu, Y., Huang, Z., Zhang, W., Guang, C.,Chen, Q.*,& Mu, W. (2022). Characterization of a Novel Mannose Isomerase from Stenotrophomonas rhizophila and Identification of Its Possible Catalytic Residues. Molecular Biotechnology, 1-10.
16.Tian, Y., Hou, X., Ni, D., Xu, W., Guang, C., Zhang, W.,Chen, Q., Rao Y., Mu, W. (2022). Structure-based interface engineering methodology in designing a thermostable amylose-forming transglucosylase. Journal of Biological Chemistry, 102074.
17.Zhang, W., Chen, D., Chen, J., Xu, W.,Chen, Q., Wu, H., Guang, C., Mu, W. (2021). D-allulose, a versatile rare sugar: recent biotechnological advances and challenges. Critical Reviews in Food Science and Nutrition, 1-19.
18.Wu, H.,Chen, Q., Zhang, W., & Mu, W. (2021). Overview of strategies for developing high thermostability industrial enzymes: Discovery, mechanism, modification and challenges.Critical Reviews in Food Science and Nutrition, 1-18.
19.Ni, D., Kırtel, O., Yin, D., Xu, W.,Chen, Q., Öner, E. T., & Mu, W. (2021). Improving the catalytic behaviors of Lactobacillus-derived fructansucrases by truncation strategies.Enzyme and Microbial Technology, 149, 109857.
20.Ni, D., Zhang, S., Kırtel, O., Xu, W.,Chen, Q., Öner, E. T., & Mu, W. (2021). Improving the Thermostability and Catalytic Activity of an Inulosucrase by Rational Engineering for the Biosynthesis of Microbial Inulin.Journal of Agricultural and Food Chemistry.
21.Zhang, W., Chen, J.,Chen, Q., Wu, H., & Mu, W. (2020). Sugar alcohols derived from lactose: lactitol, galactitol, and sorbitol.Applied Microbiology and Biotechnology, 1-9.
22.Xiao, Y.,Chen, Q., Guang, C., Zhang, W., & Mu, W.*(2019). An overview on biological production of functional lactose derivatives.Applied Microbiology and Biotechnology, 103(9), 3683-3691.
23.Xiao, Y.,Chen, Q., Shakhnovich, E. I.*, Zhang, W.*, & Mu, W. (2019). Simulation-guided enzyme discovery: A new microbial source of cellobiose 2-epimerase.International Journal of Biological Macromolecules, 139, 1002-1008.
24.Mu, W.*#,Chen, Q.#, Wang, X., Zhang, T., & Jiang, B. (2013). Current studies on physiological functions and biological production of lactosucrose.Applied Microbiology and Biotechnology, 97(16), 7073-7080.