李海涛,江南大学开云Kaiyun教授、博士生导师,国家海外高层次人才引进计划-青年项目入选者,江苏特聘教授。李海涛博士的研究方向为分子营养学,主要从事膳食营养与健康相关领域的教学和科研工作,重点围绕益生乳酸菌功能机制解析-乳酸穿梭及感知、花生四烯酸代谢-凝血噁烷支路以及相关新型食品功能因子开发与应用展开研究。主持包括国家重点研发计划子课题、国家自然科学基金及江苏特聘教授等省部级以上科研和人才项目10余项。已在Cancer Res、EBioMedicine、Carcinogenesis、Mol Nutr Food Res及J Agric Food Chem等肿瘤学及食品科学与营养领域知名期刊发表SCI论文50余篇,参编《乳酸菌科学与技术》、《Lactic Acid Bacteria in Foodborne Hazards Reduction- Physiology to Practice》专著两部。
1.国家海外高层次人才引进计划-青年项目:特殊营养学,2016/12-2019/12,主持.
2.江苏特聘教授-人才专项:肿瘤膳食营养干预,2015/10-2018/10,主持.
3.十四五”国家重点研发计划课题(2022YFF1100400):特殊生命周期医学食品创制与产业化示范,2022/12-2026/12,子课题主持
4.国家自然科学基金面上项目(No: 32272290):乳酸及乳酸受体在肠道屏障稳态中的调控作用和机制研究,2023/01-2026/12,主持
5.国家自然科学基金面上项目(No: 31972973):传统发酵食品中D-乳酸的免疫调节作用研究,2020/01-2023/12,主持
6.国家自然科学基金面上项目(No: 81773044):凝血噁烷通路在乳腺癌肺转移中的功能及分子机制研究,2018/01-2021/12,主持
7.国家自然科学基金青年基金(No: 81402366):血小板环氧合酶1耦联凝血噁烷通路共同驱动结直肠癌变的分子机制研究,2015/01-2017/12,主持
8.中央高校专项自主科研项目-重点项目(JUSRP51501):新型功能食品高通量筛选及功能机制解析,2015/07-2017/06,主持
代表性论文
1.Dai Y, Xu R, Wu G, Yin Z, Zhang H,Li H*, Chen W. Aspirin Suppresses Hepatic Glucagon Signaling through Decreasing Production of Thromboxane A2.Endocrinology. 2023 Jan 9; 164(3): bqac217.
Perry RJ.It's Not Just for Pain: A New Metabolic Function of Aspirin.Endocrinology. 2023 Feb 21: bqad036.(专家导读评议)
2.Yan Y,Li X, Yang Q, Zhang H, Hettinga K,Li H*, Chen W.Dietary D-Lactate Intake Facilitates Inflammatory Resolution by Modulating M1 Macrophage Polarization.Mol Nutr Food Res.2022. 66(24): e2200196. (封面文章)
3.XuR, YanY, ZhengX, ZhangH, ChenW,Li H*, DongZ.Aspirin Suppresses Breast Cancer Metastasis to Lung by Targeting AnoikisResistance.Carcinogenesis. 2022; 43(2):104-114.
4.Mao J, Yan Y, Li H,ShenX,Zhang H,Li H*,Chen W. Glutamine Deficiency Links Clindamycin-Induced Dysbiosis and Intestinal Barrier Dysfunction in Mice.Brit J Nutr.2021;126(3): 366-374.
5.Yao Z, Yan Y, Zheng X,Wang M,Zhang H,Li H*,Chen W. Dietary Lactate Supplementation Protects against Obesity by Promoting Adipose Browning in Mice.J Agric Food Chem.2020; 68(50): 14841-9.
6.Wang W, Chen J, Mao J, Li H,Wang M,Zhang H,Li H*,Chen W. Genistein Ameliorates Non-alcoholic Fatty Liver Disease by Targeting Thromboxane A2 Pathway.J Agric Food Chem.2018; 66(23): 5853-9.
7.Sun G, Zheng Z, Lee MH, Xu Y, Kang S, Dong Z, Wang M, Gu Z,Li H* and Chen W. Chemoprevention of Colorectal Cancer by Artocarpin, a Dietary Phytochemical fromArtocarpus heterophyllus.J Agric Food Chem.2017; 65(17): 3474-80.
8.Li H, Zhu F, Boardman LA, Wang L, Oi N, Liu K, Li X, Fu Yang, Limburg PJ, Bode AM, Dong Z*. Aspirin Prevents Colorectal Cancer by Normalizing EGFR Expression.EBioMedicine.2015; 2(5): 447-55.
Patrignani P, Dovizio M. COX-2 and EGFR: Partners in Crime Split by Aspirin.(专家导读评议)
9.Li H, Liu K, Boardman LA, Zhao Y, Wang L, Sheng Y, Oi N, Limburg PJ, Bode AM, Dong Z*. Circulating Prostaglandin Biosynthesis in Colorectal Cancer and Potential Clinical Significance.EBioMedicine.2015;2(2): 165-71.
Greenhough A, Paraskeva C, Williams AC. Circulating Prostaglandins as Biomarkers for Colorectal Cancer?EBioMedicine.2015;2(2):105-6.(专家导读评议)
10.Li H, Zhu F, Chen H, Cheng KW, Zykova T, Oi N, Lubet RA, Bode AM, Wang M, Dong Z*. 6-C-(E-phenylethenyl)-Naringenin Suppresses Colorectal Cancer Growth by Inhibiting Cyclooxygenase-1.Cancer Res.2014; 74(1): 243-52.